Article
Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.
Genes - 8 Jul 2021
Wen Jia, Xie Munan, Rowland Bryce, Rosen Jonathan D, Sun Quan, Chen Jiawen, Tapia Amanda L, Qian Huijun, Kowalski Madeline H, Shan Yue, Young Kristin L, Graff Marielisa, Argos Maria, Avery Christy L, Bien Stephanie A, Buyske Steve, Yin Jie, Choquet Hélène, Fornage Myriam, Hodonsky Chani J, Jorgenson Eric, Kooperberg Charles, Loos Ruth J F, Liu Yongmei, Moon Jee-Young, North Kari E, Rich Stephen S, Rotter Jerome I, Smith Jennifer A, Zhao Wei, Shang Lulu, Wang Tao, Zhou Xiang, Reiner Alexander P, Raffield Laura M, Li Yun
Abstract excerpt
BACKGROUND: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological trait associated variants more common in these populations have likely been missed. METHODS: To derive gene expression prediction models, we used...
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