Article
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
Cell - 17 Nov 2016
Astle William J, Elding Heather, Jiang Tao, Allen Dave, Ruklisa Dace, Mann Alice L, Mead Daniel, Bouman Heleen, Riveros-Mckay Fernando, Kostadima Myrto A, Lambourne John J, Sivapalaratnam Suthesh, Downes Kate, Kundu Kousik, Bomba Lorenzo, Berentsen Kim, Bradley John R, Daugherty Louise C, Delaneau Olivier, Freson Kathleen, Garner Stephen F, Grassi Luigi, Guerrero Jose, Haimel Matthias, Janssen-Megens Eva M, Kaan Anita, Kamat Mihir, Kim Bowon, Mandoli Amit, Marchini Jonathan, Martens Joost H A, Meacham Stuart, Megy Karyn, O'Connell Jared, Petersen Romina, Sharifi Nilofar, Sheard Simon M, Staley James R, Tuna Salih, van der Ent Martijn, Walter Klaudia, Wang Shuang-Yin, Wheeler Eleanor, Wilder Steven P, Iotchkova Valentina, Moore Carmel, Sambrook Jennifer, Stunnenberg Hendrik G, Di Angelantonio Emanuele, Kaptoge Stephen, Kuijpers Taco W, Carrillo-de-Santa-Pau Enrique, Juan David, Rico Daniel, Valencia Alfonso, Chen Lu, Ge Bing, Vasquez Louella, Kwan Tony, Garrido-Martín Diego, Watt Stephen, Yang Ying, Guigo Roderic, Beck Stephan, Paul Dirk S, Pastinen Tomi, Bujold David, Bourque Guillaume, Frontini Mattia, Danesh John, Roberts David J, Ouwehand Willem H, Butterworth Adam S, Soranzo Nicole
Abstract excerpt
Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL studies, testing 29.5 million genetic variants for association with 36 red cell, white cell, and platelet properties in 173,480 European-ancestry participants. This effort yielded hundreds of low...
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