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Article

Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies.

American journal of human genetics - 4 Aug 2022

Lu Zeyun, Gopalan Shyamalika, Yuan Dong, Conti David V, Pasaniuc Bogdan, Gusev Alexander, Mancuso Nicholas

Abstract excerpt

Transcriptome-wide association studies (TWASs) are a powerful approach to identify genes whose expression is associated with complex disease risk. However, non-causal genes can exhibit association signals due to confounding by linkage disequilibrium (LD) patterns and eQTL pleiotropy at genomic risk regions, which necessitates fine-mapping of TWAS signals. Here, we present MA-FOCUS, a multi-ancestry framework for...

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PMID: 35931050
DOI: 10.1016/j.ajhg.2022.07.002
PMCID: PMC9388396

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