Article

LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues

2019-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Long Interspersed Element 1 (LINE-1/L1) is an abundant retrotransposon that has greatly impacted human genome evolution. LINE-1s are responsible for the generation of millions of insertions in the current human population. The characterization of sporadic cases of mosaic individuals carrying pathogenic L1-insertions, suggest that heritable insertions occurs during early embryogenesis. However, t...

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Literature Corpus work: 317c0fd4-4b40-5d47-875b-0b1a8d678077
DOI: 10.1101/522623

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