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Article

Mapping of long interspersed element-1 (L1) insertions by TIPseq provides information about sub chromosomal genetic variation in human embryos.

Journal of assisted reproduction and genetics - 1 Sept 2024

Kohlrausch Fabiana B, Wang Fang, McKerrow Wilson, Grivainis Mark, Fenyo David, Keefe David L

Abstract excerpt

PURPOSE: Retrotransposons play important roles during early development when they are transiently de-repressed during epigenetic reprogramming. Long interspersed element-1 (L1), the only autonomous retrotransposon in humans, comprises 17% of the human genome. We applied the Single Cell Transposon Insertion Profiling by Sequencing (scTIPseq) to characterize and map L1 insertions in human embryos. METHODS: Sixteen...

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Source

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Identifiers

PMID: 38951360
DOI: 10.1007/s10815-024-03176-9
PMCID: PMC11405744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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