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Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells

15 Jul 2018

Abstract excerpt

Retrotransposons comprise a significant fraction of mammalian genome with unclear functions. Increasing evidence shows that they are not just remnants of ancient retroviruses but play important roles in multiple biological processes. Retrotransposons are epigenetically silenced in most somatic tissues and become reactivated in early embryos. Notably, abundant retrotransposon expression in mouse embryonic stem...

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PMID: 30123290
DOI: 10.1155/2018/6239245

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