Article

IVF-Conceived Offspring Exhibit Altered LINE-1 Retrotransposition Dynamics Associated with Long-Term Disease Risks

2025-10-30

Abstract excerpt

<h4>Background</h4> In vitro fertilization (IVF) has revolutionized reproductive medicine; however, IVF-conceived offspring exhibit a higher risk of various long-term health issues. The underlying mechanisms remain unclear. Long Interspersed Nuclear Element-1 (L1), a mobile genetic element sensitive to environmental stress, is a potential mediator. We hypothesized that the IVF procedure acts as an embryonic stres...

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Literature Corpus work: 294cc9a9-b396-5347-8b6c-ad6a9b4f17f5
DOI: 10.1101/2025.10.21.25338362

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