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Article

Assessment of genetic variation for the LINE-1 retrotransposon from next generation sequence data.

BMC bioinformatics - 28 Oct 2010

Rouchka Eric, Montoya-Durango Diego E, Stribinskis Vilius, Ramos Kenneth, Kalbfleisch Ted

Abstract excerpt

BACKGROUND: In humans, copies of the Long Interspersed Nuclear Element 1 (LINE-1) retrotransposon comprise 21% of the reference genome, and have been shown to modulate expression and produce novel splice isoforms of transcripts from genes that span or neighbor the LINE-1 insertion site. RESULTS: In this work, newly released pilot data from the 1000 Genomes Project is analyzed to detect previously unreported full...

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Identifiers

PMID: 21044359
DOI: 10.1186/1471-2105-11-S9-S12
PMCID: PMC2967742

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