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Article

L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism.

Genes & development - 1 Jun 2009

Kano Hiroki, Godoy Irene, Courtney Christine, Vetter Melissa R, Gerton George L, Ostertag Eric M, Kazazian Haig H

Abstract excerpt

Long Interspersed Element 1 (L1) is a retrotransposon that comprises approximately 17% of the human genome. Despite its abundance in mammalian genomes, relatively little is understood about L1 retrotransposition in vivo. To study the timing and tissue specificity of retrotransposition, we created transgenic mouse and rat models containing human or mouse L1 elements controlled by their endogenous promoters. Here,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19487571
DOI: 10.1101/gad.1803909
PMCID: PMC2701581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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