A regression based approach to phylogenetic reconstruction from multi-sample bulk DNA sequencing of tumors

Abstract excerpt

<h4>Motivation</h4> DNA sequencing of multiple bulk samples from a tumor provides the opportunity to investigate tumor heterogeneity and reconstruct a phylogeny of a patient’s cancer. However, since bulk DNA sequencing of tumor tissue measures thousands of cells from a heterogeneous mixture of distinct sub-populations, accurate reconstruction of the tumor phylogeny requires simultaneous deconvolution of cancer cl...

Topics

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• Algorithms
• Clonal Evolution
• Gene Frequency
• High-Throughput Nucleotide Sequencing
• Models, Statistical
• Mutation
• Neoplasms
• Sequence Analysis, DNA

Identifiers and source

Literature Corpus work

314c2bf9-6ae8-5211-a1a0-4c5ba31f94b9

DOI

10.1101/2024.04.23.590844