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Article

Estimation of cancer cell fractions and clone trees from multi-region sequencing of tumors.

Bioinformatics (Oxford, England) - 2 Aug 2022

Zheng Lily, Niknafs Noushin, Wood Laura D, Karchin Rachel, Scharpf Robert B

Abstract excerpt

MOTIVATION: Multi-region sequencing of solid tumors can improve our understanding of intratumor subclonal diversity and the evolutionary history of mutational events. Due to uncertainty in clonal composition and the multitude of possible ancestral relationships between clones, elucidating the most probable relationships from bulk tumor sequencing poses statistical and computational challenges. RESULTS: We...

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PMID: 35642899
DOI: 10.1093/bioinformatics/btac367
PMCID: PMC9344857

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