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Article

Reconstruction of clonal trees and tumor composition from multi-sample sequencing data.

Bioinformatics (Oxford, England) - 15 Jun 2015

El-Kebir Mohammed, Oesper Layla, Acheson-Field Hannah, Raphael Benjamin J

Abstract excerpt

MOTIVATION: DNA sequencing of multiple samples from the same tumor provides data to analyze the process of clonal evolution in the population of cells that give rise to a tumor. RESULTS: We formalize the problem of reconstructing the clonal evolution of a tumor using single-nucleotide mutations as the variant allele frequency (VAF) factorization problem. We derive a combinatorial characterization of the solutions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26072510
DOI: 10.1093/bioinformatics/btv261
PMCID: PMC4542783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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