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Article

Orchard: Building large cancer phylogenies using stochastic combinatorial search.

PLoS computational biology - 1 Dec 2024

Kulman Ethan, Kuang Rui, Morris Quaid

Abstract excerpt

Phylogenies depicting the evolutionary history of genetically heterogeneous subpopulations of cells from the same cancer, i.e., cancer phylogenies, offer valuable insights about cancer development and guide treatment strategies. Many methods exist that reconstruct cancer phylogenies using point mutations detected with bulk DNA sequencing. However, these methods become inaccurate when reconstructing phylogenies...

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PMID: 39775053
DOI: 10.1371/journal.pcbi.1012653
PMCID: PMC11723595

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