Back to search

Article

An electrostatic repulsion model of centromere organisation

2025-09-02

Abstract excerpt

During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome segregation. The physical principles guiding this centromere positioning remain unknown. Here, we reveal that human core centromeres are directed to the chromatin surface by repulsion of centromere-associated proteins -...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
313ad664-299b-5196-90ae-d9e0e980e4fb
DOI
10.1101/2025.09.01.673455
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An electrostatic repulsion model of centromere organisationDOI 10.1101/2025.09.01.673455
The quantitative architecture of centromeric chromatin.Semantic proximity
Defining a core configuration for human centromeres during mitosisSemantic proximity
Centromere tethering confines chromosome domains.Semantic proximity
Human centromere formation activates transcription and opens chromatin fibre structureSemantic proximity
Human centromere formation activates transcription and opens chromatin fibre structureSemantic proximity
CENP-A and CENP-B collaborate to create an open centromeric chromatin stateSemantic proximity
Epigenetic inheritance of centromere identity in a heterologous systemSemantic proximity
CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.Semantic proximity
The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-microm circle partitioning locus and promotes equal plasmid segregation.Semantic proximity
Orderly mitosis shapes interphase genome architectureSemantic proximity
<i>ZATELLITE:</i> a toolkit to visualize and manipulate human centromeres in live cells using synthetic zinc fingersSemantic proximity
Large-scale manipulation of radial positioning does not affect most aspects of genome organizationSemantic proximity
Select a neighboring publication to make it the new centre.