Article
Centromere tethering confines chromosome domains.
Molecular cell - 26 Dec 2013
Verdaasdonk Jolien Suzanne, Vasquez Paula Andrea, Barry Raymond Mario, Barry Timothy, Goodwin Scott, Forest M Gregory, Bloom Kerry
Abstract excerpt
The organization of chromosomes into territories plays an important role in a wide range of cellular processes, including gene expression, transcription, and DNA repair. Current understanding has largely excluded the spatiotemporal dynamic fluctuations of the chromatin polymer. We combine in vivo chromatin motion analysis with mathematical modeling to elucidate the physical properties that underlie the formation...
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