Article
CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.
Cell - 3 Feb 2012
Nishino Tatsuya, Takeuchi Kozo, Gascoigne Karen E, Suzuki Aussie, Hori Tetsuya, Oyama Takuji, Morikawa Kosuke, Cheeseman Iain M, Fukagawa Tatsuo
Abstract excerpt
The multiprotein kinetochore complex must assemble at a specific site on each chromosome to achieve accurate chromosome segregation. Defining the nature of the DNA-protein interactions that specify the position of the kinetochore and provide a scaffold for kinetochore formation remain key goals. Here, we demonstrate that the centromeric histone-fold-containing CENP-T-W and CENP-S-X complexes coassemble to form a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.