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Article

Orderly mitosis shapes interphase genome architecture

2025-06-03

Abstract excerpt

Genomes assume a complex 3D architecture in the interphase cell nucleus. Yet the molecular mechanisms that determine global genome architecture are only poorly understood. To identify mechanisms of higher order genome organization, we performed high-throughput imaging-based CRISPR knockout screens targeting 1064 genes encoding nuclear proteins in multiple human cell lines. We assessed changes in the distribution o...

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Literature Corpus work
4eacc5de-c4c6-56c6-87e4-b6ea3d63261b
DOI
10.1101/2025.06.03.657645
Open publication

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Orderly mitosis shapes interphase genome architectureDOI 10.1101/2025.06.03.657645
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