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Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibition

2026-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint inhibitor (ICI) combinations that block cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) signaling have revolutionized cancer care but also exert a range of immune-related adverse events (irAE) in various tissues, including the brain. Our understanding of the mechanisms of irAE in the brain is still evolving, and we recently demons...

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Literature Corpus work
3120a17d-ba64-5f05-aad7-58cd8e7e5f58
DOI
10.64898/2026.06.10.730982
Open publication

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Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibitionDOI 10.64898/2026.06.10.730982
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