Article

Deep Spatial Profiling of COVID-19 Brains Reveals Neuroinflammation by Compartmentalized Local Immune Cell Interactions and Targets for Intervention

2021-01-13

Abstract excerpt

COVID-19 can cause acute and chronic neurological symptoms. The underlying pathophysiological mechanisms, the involved immune cells, their spatial distribution, cellular interactions and the role of virus tropism remain largely unclear. Here, we deeply interrogated the brain stem and olfactory bulb in COVID-19 patients with imaging mass cytometry to understand the local immune response at a spatially resolved, hig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ca679a4-3558-5b63-b007-f53772193839
DOI: 10.2139/ssrn.3765620

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep Spatial Profiling of COVID-19 Brains Reveals Neuroinflammation by Compartmentalized Local Immune Cell Interactions and Targets for InterventionDOI 10.2139/ssrn.3765620Read

Deep spatial profiling of COVID19 brains reveals neuroinflammation by compartmentalized local immune cell interactions and targets for interventionSemantic proximity Read

Multimodal Profiling of Immune Responses Reveals Innate-Adaptive Immune Imbalance in Human Bornavirus EncephalitisSemantic proximity Read

Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibitionSemantic proximity Read

Clonal CD8 T Cells Accumulate in the Leptomeninges and Communicate with Microglia in Human NeurodegenerationSemantic proximity Read

The central nervous system’s proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2Semantic proximity Read

Spatial transcriptomics of compartmentalised inflammation in multiple sclerosisSemantic proximity Read

Spatially Resolved Microglial State Transitions Govern Strain-Specific Zika NeuropathogenesisSemantic proximity Read

High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the BrainSemantic proximity Read

Single-cell Spatial Transcriptomics Reveals Disease-specific Microenvironmental Niches in Neurodegeneration and COVID-19Semantic proximity Read

Analyzing microglial phenotypes across neuropathologies: a practical guide.Semantic proximity Read

Brain-wide alterations revealed by spatial transcriptomic and proteomic analyses in COVID-19 infectionSemantic proximity Read

The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity Read