Article

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy

2024-09-16

Abstract excerpt

<h4>Background</h4> Glioblastoma (GB) remains a formidable challenge in neuro-oncology, with immune checkpoint blockade (ICB) showing limited efficacy in unselected patients. We previously recently established that MAPK/ERK signaling is associated with overall survival following anti-PD-1 and anti-CTLA-4 treatment in recurrent GB. However, the causal relationship between MAPK/ERK signaling and susceptibility to I...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9fa8b50-c248-595b-9bb3-ab0920231a57
DOI: 10.1101/2024.09.11.612571

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacyDOI 10.1101/2024.09.11.612571Read

BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma.Semantic proximity Read

7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomasSemantic proximity Read

Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockadeSemantic proximity Read

Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibitionSemantic proximity Read

Functional profiling of murine glioma models highlights targetable immune evasion phenotypesSemantic proximity Read

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomasSemantic proximity Read

Functional profiling of murine glioma models highlights targetable immune evasion phenotypes.Semantic proximity Read

Spatially resolved single-cell analysis uncovers protein kinase Cδ-expressing microglia with anti-tumor activity in glioblastomaSemantic proximity Read

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screensSemantic proximity Read

MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomasSemantic proximity Read

Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcomeSemantic proximity Read

MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT / mTOR pathwaySemantic proximity Read