Article

Molecular basis of DNA recognition by the HMG-box-C1 module of Capicua

2022-03-29

Abstract excerpt

The HMG-box protein Capicua (CIC) is an evolutionarily conserved transcriptional repressor with key functions in development and disease-associated processes. CIC binds DNA using an exclusive mechanism that requires both its HMG-box and a separate domain called C1, but how these domains cooperate to recognize specific DNA sequences is not known. Here we report the crystal structure of the human CIC HMG-box and C1...

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Literature Corpus work: 304289db-af6c-58d0-aeee-dec739f167fe
DOI: 10.1101/2022.03.28.485992

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