Article

The <i>Capicua</i> C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein

2024-06-09

Abstract excerpt

Rearrangements between genes can yield neomorphic fusions that drive oncogenesis. Fusion oncogenes are made up of fractional segments of the partner genes that comprise them, with each partner potentially contributing some of its own function to the nascent fusion oncoprotein. Clinically, fusion oncoproteins driving one diagnostic entity are typically clustered into a single molecular subset and are often treated...

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Literature Corpus work: eca2785f-05dc-5978-8ee4-1e8dab717fdb
DOI: 10.1101/2024.06.06.597815

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