Article

Decoding the mechanisms of cooperative DNA binding by the Paired-like homeodomain family

2025-10-30

Abstract excerpt

The 36 Paired-like homeodomain transcription factors are required for the development of many cell types, tissues, and organs as missense variants in 24 genes are associated with a variety of diseases and developmental disorders. How these factors identify distinct genomic targets using highly similar DNA binding domains is not fully understood. Here, we focus on determining how the Paired-like homeodomain factors...

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Literature Corpus work: b7cf6d32-c95b-5a29-a43b-4d350ae48bba
DOI: 10.1101/2025.10.29.685385

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