Article
Molecular basis of DNA recognition by the HMG-box-C1 module of capicua.
Structure (London, England : 1993) - 4 Dec 2025
Webb Jonathan, Liew Jeremy J M, Gnann Andrew D, Ilkhani Khandan, Patterson MacKenzie, Paul Sayantanee, Forés Marta, Jiménez Gerardo, Veraksa Alexey, Dowling Daniel P
Abstract excerpt
The HMG-box protein capicua (CIC) is a conserved transcriptional repressor with key functions in development and disease. CIC binding of DNA requires both its HMG-box and a separate domain called C1. How these domains cooperate to recognize specific DNA sequences is not known. Here, we report the crystal structure of the human CIC HMG-box and C1 domains complexed with a DNA oligomer containing a consensus...
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