Article
The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.
The Journal of biological chemistry - 10 Sept 2004
Pinte Sébastien, Stankovic-Valentin Nicolas, Deltour Sophie, Rood Brian R, Guérardel Cateline, Leprince Dominique
Abstract excerpt
HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene located at chromosome 17p13.3, a region frequently hypermethylated or deleted in human tumors and in a contiguous-gene syndrome, the Miller-Dieker syndrome. HIC1 is a transcriptional repressor containing five Krüppel-like C(2)H(2) zinc fingers and an N-terminal dimerization and autonomous repression domain called BTB/POZ. Although some of the HIC1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.