Article

CIC is a Critical Regulator of Neuronal Differentiation

2019-10-09

Abstract excerpt

<h4>ABSTRACT</h4> Capicua (CIC), a member of the high mobility group (HMG)-box superfamily of transcriptional repressors, is frequently mutated in human oligodendrogliomas. But its function in brain development and tumorigenesis remains poorly understood. Here, we report that brain-specific deletion of Cic compromises developmental transition of neuroblast to immature neurons in mouse hippocampus and compromises...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50c0509f-6d58-50c4-bf8e-f220ef6c340f
DOI: 10.1101/799536

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CIC is a Critical Regulator of Neuronal DifferentiationDOI 10.1101/799536Read

Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factorsSemantic proximity Read

Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.Semantic proximity Read

Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.Semantic proximity Read

Multi-omic analysis of CIC’s functional networks reveals novel interaction partners and a potential role in mitotic fidelitySemantic proximity Read

Molecular basis of DNA recognition by the HMG-box-C1 module of CapicuaSemantic proximity Read

Non-coding structural variants identify a commonly affected regulatory region steering<i>FOXG1</i>transcription in early neurodevelopmentSemantic proximity Read

Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signatureSemantic proximity Read

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer.Semantic proximity Read

STAG2 promotes the myelination transcriptional program in oligodendrocytesSemantic proximity Read

Disruption of <i>Histone H4C</i> genes impairs skeletal development and cortical neurogenesis, modeling rare neurodevelopmental syndromesSemantic proximity Read

The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin‐remodeling complexSemantic proximity Read

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.Semantic proximity Read