Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer.

PLoS genetics - 1 Mar 2017

Forés Marta, Simón-Carrasco Lucía, Ajuria Leiore, Samper Núria, González-Crespo Sergio, Drosten Matthias, Barbacid Mariano, Jiménez Gerardo

Abstract excerpt

HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-box transcriptional repressor involved in Ras/MAPK signaling and cancer progression, employs an additional distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to High Mobility Group Proteins

Share to HMGB Proteins

Share to Homeodomain Proteins

Share to Microscopy, Confocal

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 28278156
DOI: 10.1371/journal.pgen.1006622
PMCID: PMC5344332

Genes

CIC
DUX4
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer.PMID 28278156Read ↗

Molecular basis of DNA recognition by the HMG-box-C1 module of CapicuaSemantic proximity Read ↗

Molecular basis of DNA recognition by the HMG-box-C1 module of capicua.Semantic proximity Read ↗

The <i>Capicua</i> C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion OncoproteinSemantic proximity Read ↗

CIC is a Critical Regulator of Neuronal DifferentiationSemantic proximity Read ↗

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancerSemantic proximity Read ↗

CIC-Rearranged Sarcomas: An Intriguing Entity That May Lead the Way to the Comprehension of More Common CancersSemantic proximity Read ↗

The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations.Semantic proximity Read ↗

Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice.Semantic proximity Read ↗

Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse modelsSemantic proximity Read ↗

Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse modelsSemantic proximity Read ↗

A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks.Semantic proximity Read ↗

The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.