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Article

Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.

Genes & development - 15 Jan 1997

Jacobson E M, Li P, Leon-del-Rio A, Rosenfeld M G, Aggarwal A K

Abstract excerpt

Pit-1, a member of the POU domain family of transcription factors, characterized by a bipartite DNA-binding domain, serves critical developmental functions based on binding to diverse DNA elements in its target genes. Here we report a high resolution X-ray analysis of the Pit-1 POU domain bound to a DNA element as a homodimer. This analysis reveals that Pit-1 subdomains bind to perpendicular faces of the DNA,...

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Identifiers

PMID: 9009203
DOI: 10.1101/gad.11.2.198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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