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Article

A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks.

Nucleic acids research - 20 Jun 2016

Zhang Kuo, Gao Yuan, Li Jingjing, Burgess Rebecca, Han Junhong, Liang Huanhuan, Zhang Zhiguo, Liu Yingfang

Abstract excerpt

Chromatin assembly factor 1 (CAF-1) is a histone H3-H4 chaperone that deposits newly synthesized histone (H3-H4)2 tetramers during replication-coupled nucleosome assembly. However, how CAF-1 functions in this process is not yet well understood. Here, we report the crystal structure of C terminus of Cac1 (Cac1C), a subunit of yeast CAF-1, and the function of this domain in stabilizing CAF-1 at replication forks....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26908650
DOI: 10.1093/nar/gkw106
PMCID: PMC4914081

Genes

PCNA

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