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Human PCNA Structure, Function and Interactions

8 Apr 2020

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA polymerases and other DNA editing enzymes. It also interacts with regulatory proteins through a sequence motif known as PCNA Interacting Protein box (PIP-box). We here review the latest contributions to knowledge regarding the...

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PMID: 32276417
DOI: 10.3390/biom10040570

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