Article
Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010
Akai Yusuke, Adachi Naruhiko, Hayashi Yohei, Eitoku Masamitsu, Sano Norihiko, Natsume Ryo, Kudo Norio, Tanokura Masaru, Senda Toshiya, Horikoshi Masami
Abstract excerpt
Nucleosomes around the promoter region are disassembled for transcription in response to various signals, such as acetylation and methylation of histones. Although the interactions between histone-acetylation-recognizing bromodomains and factors involved in nucleosome disassembly have been reported, no structural basis connecting histone modifications and nucleosome disassembly has been obtained. Here, we...
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