Article

Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury

2025-09-08

Abstract excerpt

CNS has an overall higher level of lipids than all tissues except adipose and contains up to 25% of total body cholesterol. Recent data demonstrate a complex crosstalk between lipid metabolism and inflammation, suggesting potential contribution of the lipid-rich brain environment to neuroinflammation. While recent data support the importance of brain lipid environment to inflammatory changes observed in age relate...

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Literature Corpus work: 3030bfca-212e-5f31-b45a-94eba7cef437
DOI: 10.1101/2025.09.04.674092

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