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Article

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration.

Science advances - 10 Mar 2023

Ritzel Rodney M, Li Yun, Jiao Yun, Lei Zhuofan, Doran Sarah J, He Junyun, Shahror Rami A, Henry Rebecca J, Khan Romeesa, Tan Chunfeng, Liu Shaolin, Stoica Bogdan A, Faden Alan I, Szeto Gregory, Loane David J, Wu Junfang

Abstract excerpt

Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate that in comparison to young mice, one-third of old microglia are AF, characterized by profound changes in lipid and iron content, phagocytic activity, and oxidative...

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Identifiers

PMID: 36888713
DOI: 10.1126/sciadv.add1101
PMCID: PMC9995070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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