Article

Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells

2025-09-17

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive motor neuron loss, with TDP-43 pathology present in over 90% of cases. While neuroinflammation is a recognized hallmark, the role of microglia in ALS pathogenesis remains incompletely understood. Here, we demonstrate that TDP-43 regulates microglial function via triglyceride metabolism. Using shRNA-mediated TARDBP knock...

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Literature Corpus work: d0fdf8bf-b0f0-5a2a-8dd4-129f9807ab5b
DOI: 10.1101/2025.09.17.676815

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