Article

Alzheimer's-associated upregulation of mitochondria-associated ER membranes after traumatic brain injury

2020-11-15

Abstract excerpt

Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer disease (AD) through mechanisms that remain incompletely characterized. Similar to AD, TBI models present with cellular metabolic alterations and modulated cleavage of amyloid precursor protein (APP). Specifically, AD and TBI tissues display increases in amyloid-beta; as well as its precursor, APP C-terminal fragment of 99 a.a. (...

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Literature Corpus work: 9d570be7-b0af-56a2-87c6-f5d154cc2dd6
DOI: 10.1101/2020.11.13.381756

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