Article

Age-related Dysregulation of Autophagy Contributes to Microglial Dysfunction and Chronic Neurobehavioral Deficits After Traumatic Brain Injury

2021-11-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Elderly patients with traumatic brain injury (TBI) have greater mortality and poorer outcomes than younger individuals. Given the critical role for autophagy in promoting the cellular degradation of damaged organelles and the negative impact of aging on this protective mechanism, we hypothesized that treatment with an autophagic inducer such as trehalose may be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f2867c3-aba5-5294-8812-4597214be56a
DOI: 10.21203/rs.3.rs-1021695/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Age-related Dysregulation of Autophagy Contributes to Microglial Dysfunction and Chronic Neurobehavioral Deficits After Traumatic Brain InjuryDOI 10.21203/rs.3.rs-1021695/v1Read

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in miceSemantic proximity Read

Microglia and infiltrating T-cells adopt long-term, age-specific, transcriptional changes after traumatic brain injurySemantic proximity Read

Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injurySemantic proximity Read

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration.Semantic proximity Read

Autophagy and Microglia: Novel Partners in Neurodegeneration and AgingSemantic proximity Read

Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injurySemantic proximity Read

Mitophagy in Traumatic Brain Injury: A New Target for Therapeutic InterventionSemantic proximity Read

Role of Microglia Autophagy in Microglia Activation After Traumatic Brain InjurySemantic proximity Read

Dual Roles of Autophagy in Radiation‐Induced Brain Injury: Mechanistic Insights and Therapeutic ImplicationsSemantic proximity Read

Rubicon modulates neuroimmune responses following traumatic brain injurySemantic proximity Read

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged MiceSemantic proximity Read

Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humansSemantic proximity Read