Article

Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury

2025-10-21

Abstract excerpt

<title>Abstract</title> <p>CNS has an overall higher level of lipids than all tissues except adipose and contains up to 25% of total body cholesterol. Recent data demonstrate a complex crosstalk between lipid metabolism and inflammation, suggesting potential contribution of the lipid-rich brain environment to neuroinflammation. While recent data support the importance of brain lipid environment to inflammatory ch...

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Literature Corpus work: 0c434c1b-2ec7-5bca-b9c6-166ae4828eb2
DOI: 10.21203/rs.3.rs-7682363/v1

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