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Identification of novel drug targets for Alzheimer's disease by integrating genetics and proteomes from brain and blood.

Molecular psychiatry - 1 Oct 2021

Ou Ya-Nan, Yang Yu-Xiang, Deng Yue-Ting, Zhang Can, Hu Hao, Wu Bang-Sheng, Liu Yi, Wang Yan-Jiang, Zhu Ying, Suckling John, Tan Lan, Yu Jin-Tai

Abstract excerpt

Genome-wide association studies (GWASs) have discovered numerous risk genes for Alzheimer's disease (AD), but how these genes confer AD risk is challenging to decipher. To efficiently transform genetic associations into drug targets for AD, we employed an integrative analytical pipeline using proteomes in the brain and blood by systematically applying proteome-wide association study (PWAS), Mendelian...

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PMID: 34381170
DOI: 10.1038/s41380-021-01251-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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