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Article

Immune cell-specific genetic architecture of Alzheimer's disease revealed by multi-omics analysis for therapeutic target discovery and prioritization.

Translational psychiatry - 23 Jun 2026

Gao Tian-Long, Geng Shan, Chen Jia, Yang Liu, Nie Yun-Juan, Yu Haitao, Chai Gao-Shang

Abstract excerpt

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition in which accumulating genetic and molecular evidence implicates dysregulation of peripheral immune processes in disease pathogenesis. Nevertheless, the contribution of distinct peripheral immune cell subsets and associated gene regulatory landscapes to AD risk remains incompletely defined. To address this gap, we integrated single-cell...

Read the complete abstract on PubMed

Topics

Humans
Alzheimer Disease
Quantitative Trait Loci
Genome-Wide Association Study
Multiomics
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

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Identifiers

PMID: 42331779
DOI: 10.1038/s41398-026-04199-9
PMCID: PMC13538538

Genes

BIN1
GSTP1
PM20D1
B4GALNT3
CNN2

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