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Article

Role of the Topoisomerase IIα Chromatin Tether domain in Nucleosome Binding & Chromosome Segregation

2021-10-03

Abstract excerpt

Due to the intrinsic nature of DNA replication, replicated genomes retain catenated genomic loci that must be resolved to ensure faithful segregation of sister chromatids in mitosis. Type II DNA Topoisomerase (TopoII) decatenates the catenated genomic DNA through its unique Strand Passage Reaction (SPR). Loss of SPR activity results in anaphase chromosome bridges and formation of P olo-like Kinase I nteracting...

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Literature Corpus work
3005b92c-b0bc-5661-bb51-5dba013270f4
DOI
10.1101/2021.10.03.462934
Open publication

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Role of the Topoisomerase IIα Chromatin Tether domain in Nucleosome Binding & Chromosome SegregationDOI 10.1101/2021.10.03.462934
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