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Article

A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres.

The EMBO journal - 16 Sept 2009

Germe Thomas, Miller Kyle, Cooper Julia Promisel

Abstract excerpt

The decatenation activity of topoisomerase II (Top2), which is widely conserved within the eukaryotic domain, is essential for chromosomal segregation in mitosis. It is less clear, however, whether Top2 performs the same function uniformly across the whole genome, and whether all its functions rely on decatenation. In the fission yeast, Schizosaccharomyces pombe, telomeres are bound by Taz1, which promotes smooth...

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Identifiers

PMID: 19680223
DOI: 10.1038/emboj.2009.223
PMCID: PMC2750024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres.PMID 19680223Read ↗

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