Article

Substrate accessibility regulation of human TopIIa decatenation by cohesin

2023-11-21

Abstract excerpt

Human topoisomerase II alpha (TOP2α) is the main mitotic decatenase 1–3 resolving intertwines between sister chromatids that form during DNA replication 4 . Here, we employ quadruple-trap optical tweezers to generate braids between a pair of λ-DNA molecules to study, at the single-molecule level and in real-time, how TOP2α untangles these DNAs. We find that TOP2α rapidly resolves single and multiple braids and i...

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Literature Corpus work: f2d0a6d5-d2b6-580f-a175-8fda232ae37c
DOI: 10.1101/2023.11.20.567865

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