Article

Single-cell characterization and machine learning-based classification reveal the transcriptional identity and antigen-experienced features of peripheral CD4⁺CD8⁺ double-positive T cells

2026-01-02

Abstract excerpt

T cell mediated immunity depends on diverse subsets with distinct regulatory and cytotoxic roles. While CD4⁺ and CD8⁺ T cells have traditionally been viewed as separate lineages, double-positive T (DPT) cells coexpressing both markers have emerged as a rare subset with potential roles in immune modulation, cytotoxicity, and memory. Here, we integrated single-cell RNA sequencing, single-cell TCR sequencing, and sup...

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Literature Corpus work: 3000e09d-465d-5b15-a619-f658e295926a
DOI: 10.64898/2026.01.01.697324

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