Article

Human MAIT cells show clonal diversity but transcriptional and functional homogeneity

2022-03-01

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells are considered to have limited clonal diversity. In contrast, recent studies suggest the presence of functionally distinct subsets. We investigated this model through single-cell analysis of the MAIT cell TCR repertoire and transcriptional profile in human blood and liver. Further, we developed functional RNA-sequencing (fRNA-seq), an approach to integrate cellular funct...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de4bd63f-f28d-5d4a-9c0e-2f21e886f189
DOI: 10.1101/2022.02.26.482031

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human MAIT cells show clonal diversity but transcriptional and functional homogeneityDOI 10.1101/2022.02.26.482031Read

Single-Cell Analysis Reveals Tissue-Specific T Cell Adaptation and Clonal Distribution Across the Human Gut-Liver-Blood AxisSemantic proximity Read

Single cell resolution analysis of multi-tissue derived human iNKT cells reveals novel transcriptional paradigmsSemantic proximity Read

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activationSemantic proximity Read

Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies.Semantic proximity Read

Single-cell characterization and machine learning-based classification reveal the transcriptional identity and antigen-experienced features of peripheral CD4⁺CD8⁺ double-positive T cellsSemantic proximity Read

MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profilesSemantic proximity Read

Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditionsSemantic proximity Read

A genome-wide innateness gradient defines the functional state of human innate T cellsSemantic proximity Read

Tissue determinants of the human T cell receptor repertoire.Semantic proximity Read

Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse ModelsSemantic proximity Read

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organsSemantic proximity Read

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture in humansSemantic proximity Read