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Article

High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells.

Nature immunology - 1 Dec 2021

Ma Ke-Yue, Schonnesen Alexandra A, He Chenfeng, Xia Amanda Y, Sun Eric, Chen Eunise, Sebastian Katherine R, Guo Yu-Wan, Balderas Robert, Kulkarni-Date Mrinalini, Jiang Ning

Abstract excerpt

Although critical to T cell function, antigen specificity is often omitted in high-throughput multiomics-based T cell profiling due to technical challenges. We describe a high-dimensional, tetramer-associated T cell antigen receptor (TCR) sequencing (TetTCR-SeqHD) method to simultaneously profile cognate antigen specificities, TCR sequences, targeted gene expression and surface-protein expression from tens of...

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Identifiers

PMID: 34811538
DOI: 10.1038/s41590-021-01073-2
PMCID: PMC9184244

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