Article

VDJdive and ECLIPSE enhance single-cell TCR sequencing analysis through the probabilistic resolution of ambiguous clonotypes

2026-02-20

Abstract excerpt

Single-cell T cell receptor sequencing (scTCR-seq) has transformed our ability to track individual T cell clones and has been instrumental in advancing our understanding of human T cell differentiation. However, current computational pipelines for analysis, which require precise matching of CDR3 sequences from exactly 2 heterodimeric TCR chains to define the clonotype for each cell, are inherently limited because...

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Literature Corpus work: 00ce94df-b0bb-506e-8a44-7a920bafd0fc
DOI: 10.64898/2026.02.18.706444

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