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Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions

1 Sept 2025

Abstract excerpt

Abstract T cells recognize antigens and induce specialized gene expression programs (GEPs), enabling functions like proliferation, cytotoxicity and cytokine production. Traditionally, different T cell classes are thought to exhibit mutually exclusive responses, including T H 1, T H 2 and T H 17 programs. However, single-cell RNA sequencing has revealed a continuum of T cell states without clearly distinct...

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PMID: 40903640
DOI: 10.1038/s41592-025-02793-1

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