Article

High-Throughput and High-Dimensional Single Cell Analysis of Antigen-Specific CD8 <sup>+</sup> T cells

2021-03-05

Abstract excerpt

Although critical to T cell function, antigen specificity is often omitted in high-throughput multi-omics based T cell profiling due to technical challenges. We describe a high-dimensional, tetramer-associated T cell receptor sequencing (TetTCR-SeqHD) method to simultaneously profile TCR sequences, cognate antigen specificities, targeted gene-expression, and surface-protein expression from tens of thousands of sin...

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Literature Corpus work: 2bb21baa-07ed-5862-a41f-02ea887d2878
DOI: 10.1101/2021.03.04.433914

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