Article

Deciphering Cell Fate and Clonal Dynamics via Integrative Single-Cell Lineage Modeling

2025-09-04

Abstract excerpt

Through natural or synthetic lineage barcodes, single-cell technologies now enable the joint measurement of molecular states and clonal identities, providing an unprecedented opportunity to study cell fate and dynamics. Yet, most computational methods for inferring cell development and differentiation rely exclusively on transcriptional similarity, overlooking the lineage information encoded by lineage barcodes. T...

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Literature Corpus work: 4204691a-53ec-52a0-a63e-4b6be2badc45
DOI: 10.1101/2025.09.01.673503

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