Article

moPPIt: <i>De Novo</i> Generation of Motif-Specific and Functionally Active Peptide Binders via Discrete Flow Matching

2024-08-01

Abstract excerpt

Targeting specific functional motifs, whether conserved viral epitopes, intrinsically disordered regions (IDRs), or fusion breakpoints, is essential for modulating protein function and protein-protein interactions (PPIs). Current design methods, however, depend on stable tertiary structures, limiting their utility for disordered or dynamic targets. Here, we present a mo tif-specific PPI t argeting algorithm ( m...

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Literature Corpus work: 2fec56f1-5994-50d6-8263-e473a2209f03
DOI: 10.1101/2024.07.31.606098

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